Role of the Clinical Pathology Laboratory

in the Evaluation of Lynch

Syndrome-related Gynecological Cancers

Presented by:

Russell R. Broaddus, MD, PhD - University of Texas

MD Anderson Cancer Clinic 


Lynch Syndrome increases the lifetime risk of endometrial cancer to 25% - 60% and

ovarian cancer to 4 - 12%. Approximately 30% of Lynch Syndrome related ovarian cancers are diagnosed before 40 years of age. While the importance of proper surveillance, chemoprevention, and risk-reducing surgeries are well known when constructing an appropriate care plan, often overlooked is the critical role of the clinical pathology laboratory in the evaluation of Lynch Syndrome-related gynecological cancers. 


The “Gynecological Pathology in Lynch Syndrome” webinar will be a source of information

for primary care physicians, surgeons, gastroenterologists, genetic counselors, and nurses and will include education on the following topics: 


  • Immunohistochemistry for Mismatch Repair Proteins

  • Microsatellite Instability Analysis

  • MLH1 Promoter Methylation Analysis

  • Pitfalls in Test Interpretation

  • Discrepancies between Tissue Testing and Genetic Testing

  • Approaches to Screening for Lynch Syndrome-related Gynecological Cancers

  • Pathological features of Lynch Syndrome-related Gynecological Cancers

  • Implications of Pathology Reports as it Relates to Gynecological Prophylaxis 


Learning Outcomes


At the conclusion of this webinar, medical professionals will be able to:


  • Communicate how pathology impacts the care plan for Lynch Syndrome. 

  • Summarize the pitfalls in test interpretation. 

  • Give examples of discrepancies between tissue testing and genetic testing. 


Registration Information


8 Part Webinar Series: $55* by February 20th

8 Part Webinar Series: $60* after February 20th



CEU Information



The National Society of Genetic Counselors (NSGC) has authorized the Hereditary Colon Cancer Foundation to offer up to 0.8 CEUs or 8.0 contact hours (Category 1) for Preparing to Treat Polyposis Conditions. The American Board of Genetic Counseling (ABGC) will accept CEUs earned at this program for the purposes of certification and recertification. 


*At the time of registration, a one time $25 fee will be added for the individual's application to the NSGC for CEUs. 


Genetic Counselors may attend the sessions LIVE or wait for the On-Demand recorded webinars.



According to the criteria of the American Board of Certification for Gastroenterology Nurses (ABCGN), 3 hour(s) earned in this activity are considered GI Specific for the purpose of recertification by contact hours through the ABCGN.



This conference has been approved by the Canadian Association of Genetic Counsellors (CAGC) for 7 CECs.


Refund Policy


Registration fees cover the cost of CEUs, production and promotion of the webinar series. Proceeds benefit the Hereditary Colon Cancer Foundation. If you would like to receive a refund, please email 24 hours prior to the first webinar(s) start time. Refunds will exclude a 10% processing fee.

Live: September 15, 2016 @ 1:00 p.m. EST
On Demand: September 19, 2016

ALL Webinars are available